#22.16
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If the last domino is the same in both cases, how do the different responses come about? The answer is complex and is still being deciphered; however, part of the solution appears to lie in the ability of Ste12 to associate with different partners. Ste12 functions as a dimer and, depending on the identity of its partner, will activate a different set of genes. Thus, low nitrogen levels promote the association of Ste12 with one partner (and activation of a specific set of genes), while mating factor promotes association with another partner (and activation of another set of genes). Further experimentation is needed for a more complete understanding of this enigma.